Simvastatin
Known By Tradename :
Simvastatin Tablets, Zocor, Zocor Simvastatin, Zocor Tablet, Zocor Tablets,
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Companies That Produce This Drug :
A Q Pharmaceutical, United States
Allscripts Healthcare Solutions Llc, United States
Amerisource Health Services Corp, United States
Cardinal Health Germany, United States
Dhhs Program Support Center Supply Service Center, United States
Direct Dispensing Inc, United States
Drx Pharmaceutical Consultants Inc, United States
Kaiser Fdn Hosp, United States
Med Pro Inc, United States
Merck And Co Inc, United States
Merck Sharp And Dohme Ltd, United Kingdom
Murfreesboro Pharmaceutical Nursing Supply, United States
Nucare Pharmaceuticals Inc, United States
Pca Llc, United States
Pharmaceutical Utilization Management Program Va Inc, United States
Physicians Total Care Inc, United States
Prepackage Specialists, United States
Southwood Pharmaceuticals Inc, United States
Va Cmop Dallas, United States
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What It Is Used For :
HMG-CoA Reductase Inhibitors (Statins) (Antilipid Agents)
Miscellaneous Antilipid Agents
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Known Precautions and Warnings :
Clofibrate interacts with Simvastatin
Avoid this drug combination if possible. This drug combination, however, may be beneficial in patients with severe hyperlipidemias. Monitor patients for signs of muscle pain and weakness. Max dose is10mg/day.
Resulting In: myopathy Concomitant use of Clofibrate and Simvastatin can potentiate some adverse effects.
Daptomycin interacts with Simvastatin
Consider temporarily suspending use of simvastatin during treatment with Cubicin.
Coadministration of Daptomycin and Simvastatin may have an increased risk of myopathy.
Fenofibrate interacts with Simvastatin
Use with caution. Periodic monitoring of creatinine kinase and renal function. Max dose is 10mg/day.
Resulting In: Rhabdomyolysis Concomitant administration of Fenofibrate and Simvastatin may cause toxicity of both agents.
Imatinib mesylate interacts with Simvastatin
Monitor for signs and symptoms of adverse effects especially muscle weakness and cramping. Lower the dose of simivastatin if needed.
Imatinib mesylate may increase serum levels of Simvastatin.
Simvastatin interacts with Amiodarone HCl
Use with caution together, limit dose of SIMVASTATIN to 20mg.
Resulting In: Rhabdomyolysis Concomitant administration of Amiodarone HCl and Simvastatin may increase the risk of Simvastatin toxicity.
Simvastatin interacts with Cyclosporine
Increase risk of myopathy/rhabdomyolysis. Therapy should begin with 5mg/day and should not exceed 10mg/day.
Resulting In: Rhabdomyolysis, myopathy Cyclosporine may increase blood levels of Simvastatin.
Simvastatin interacts with Gemfibrozil
Avoid this drug combination if possible. This drug combination, however, may be beneficial in patients with severe hyperlipidemias. Monitor patients for signs of muscle pain and weakness. The recommended Max dose in these cases is 10mg/day.
Resulting In: Rhabdomyolysis Concomitant use of Simvastatin and Gemfibrozil can potentiate some adverse effects.
Simvastatin interacts with Nefazodone HCl
Ask patient to report any unexplained muscle weakness, pain or tenderness. Fluvastatin or Pravastatin may be safer alternatives.
Resulting In: Polymyositis, Rhabdomyolysis Nefazodone HCl can increase the serum levels of Simvastatin and increase the risk of toxicity.
Simvastatin interacts with Niacin
This drug combination may be beneficial in patients with severe hyperlipidemias. Weigh the benefits vs risks and monitor patients for signs of muscle pain and weakness. Max dose of simvastatin is 10mg/day.
Resulting In: myopathy Concomitant administration of Niacin and Simvastatin may increase the risk of Simvastatin toxicity.
Simvastatin interacts with Verapamil HCl
Avoid this combination if possible; if not, use a lower dose of HMG-CoA REDUCTASE INHIBITOR. Ask patient to report any muscle pain and tenderness. Max dose is 20mg/day. Safer alternatives are Fluvastatin and Pravastatin.
Resulting In: Polymyositis, Rhabdomyolysis Verapamil HCl can increase the serum levels of Simvastatin and increase the risk of toxicity.
Simvastatin interacts with Warfarin Sodium
Monitor coagulation factors when starting or stopping HMG-CoA REDUCTASE INHIBITOR. Atorvastatin, Cerivastatin and Pravastatin do not seem to interact with WARFARIN.
Simvastatin can increase the anticoagulant effects of Warfarin Sodium.
Telithromycin interacts with Simvastatin
Avoid this combination. May use pravastatin or fluvastatin.
Resulting In: Rhabdomyolysis, myopathy Telithromycin may increase blood levels of Simvastatin.
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